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Faculty of MedicineHackett Lab | Department of Anesthesiology, Pharmacology, & Therapeutics
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  • Our goal is to improve the health of patients living with asthma and COPD, who are challenged every day with the simple task of breathing.

  • We investigate the underlying cellular, molecular, and genetic abnormalities responsible for lung disease pathobiology.

  • Our research uses ultra-resolution imaging to detect microscopic early disease, which is undetectable using current clinical tests.

  • Our research objectives are to provide new approaches to predict risk, diagnose, and discover new treatments to improve the quality of life for patients with asthma and COPD .

  • The Hackett lab is located at the UBC Centre for Heart Lung Innovation, St. Paul’s Hospital, Vancouver.

  • It’s Happening! The New St. Paul’s Hospital will open at False Creek flats in 2027.

Lab News

May, 2025

Congratulations to Dr. Tillie Hackett, recipient of the 2025 Killam Teaching Prize!


2024

Congratulations to Kauna for successfully defending her PhD thesis!


2024

Congratulations to Kingsley for successfully defending his PhD thesis!


Aug, 2023

Our lab was featured in the Daily Scan / Providence Health Care website.


June, 2023

Congrats to Aileen Hsieh: her research project presented at ATS was highlighted in the Providence Research Report.


May, 2022

Congratulations to Dr. Tillie Hackett for being honoured at the 2022 Faculty of Medicine Academic Gowns and Emeriti Recognition Ceremony, recognizing her promotion to Professorship!

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Recent Publications

  • Effect of age, COPD severity, and cigarette smoke exposure on bronchial epithelial barrier function. Am J Physiol Lung Cell Mol Physiol. 2025 May 1;328(5):L724-L737.

  • Cellular and molecular features of asthma mucus plugs provide clues about their formation and persistence. J Clin Invest. 2025 Mar 17;135(6):e186889.

  • Airway remodeling heterogeneity in asthma and its relationship to disease outcomes. Front Physiol. 2023; 14: 1113100.

  • Bioengineering lungs: An overview of current methods, requirements, and challenges for constructing scaffolds. Front Bioeng Biotechnol. 2022; 10: 1011800.

  • Arterial remodelling in smokers and in patients with small airway disease and COPD: implications for lung physiology and early origins of pulmonary hypertension. ERJ Open Res. 2022 Dec 5;8(4):00254-2022.

  • The relation between age and airway epithelial barrier function. Respir Res. 2022 Mar 3;23(1):43.

  • Angiotensin-Converting Enzyme 2 (ACE2), Transmembrane Peptidase Serine 2 (TMPRSS2), and Furin Expression Increases in the Lungs of Patients with Idiopathic Pulmonary Fibrosis (IPF) and Lymphangioleiomyomatosis (LAM): Implications for SARS-CoV-2 (COVID-19) Infections. J Clin Med. 2022 Jan 31;11(3):777.

  • The Role of the Dynamic Lung Extracellular Matrix Environment on Fibroblast Morphology and Inflammation. Cells. 2022 Jan 6;11(2):185.
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Funding Partners


 

 

 

 

 

 

 

 

 

 

 

 

 

 

Hackett Lab | Department of Anesthesiology, Pharmacology, & Therapeutics
Faculty of Medicine
1081 Burrard Street
Rm 166
Vancouver, BC Canada V6Z 1Y6
Tel 604 806 8346
Fax 604 806 8351
Email info@hli.ubc.ca
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